Bioinformatician

To support the growth of our Computational Biology unit, we are looking for a highly motivated and qualified bioinformatician, specializing in comparative genomics and long-read sequencing, to join our team and play a crucial role in our research and development efforts. 👩‍🔬

The bioinformatician specializing in nanopore sequencing and comparative genomics will play a critical role in advancing our understanding of genomic functions and structures within fungal and bacterial strains, which are essential for innovative biorefining and bioremediation processes. This position requires in-depth expertise in genomics, specifically in the analysis of long sequencing reads using Nanopore technology and the performance of comparative genomic studies. 📊

The successful candidate will be responsible for conducting in-depth literature reviews, data mining, and evolutionary analysis to identify and interpret genes crucial to biorefinery and bioremediation applications. In addition, they will manage the assembly of sequencing data, quality control and functional annotation, thus contributing significantly to the enrichment of the MycoBank database. The ideal candidate will have a strong background in bioinformatics or a closely related field, coupled with proven experience in a dynamic and collaborative research environment.

👉 Responsibilities: Nanopore Sequencing

Quality control of sequencing reads

• Performing initial quality assessments on long sequencing reads obtained via Nanopore technology

• Use bioinformatics tools to filter and clean data, ensuring high-quality inputs for further analysis.

Assembly and annotation

• Assembling cleaned long reads into a coherent genomic sequence

• Perform functional genome annotation to identify and categorize genes based on their predicted functions

Collaboration on the MycoBank database

• Work with a team to integrate sequencing data into the MycoBank database

• Ensure that data is well organized and accessible, thus improving the usefulness of the database for Novobiom's internal development

👉 Responsibilities: Comparative Genomics

Documentary investigation and data mining

• To study the existing literature to identify genes involved in critical biorefinery and bioremediation processes

• Use data mining techniques to consolidate and summarize results related to key enzyme steps and metabolic pathways

Study of evolutionary pathways

• Analyzing the evolutionary history of specific genes in fungal and bacterial strains

• Use phylogenetic tools and databases to track gene evolution and understand functional adaptations

Data analysis and interpretation

• Collaborate on various genetic data analysis projects, research for models and information related to the biorefinery

• Use statistical tools and bioinformatics software to interpret results and contribute to scientific discussions

🎓 Formation:

Master's degree or higher in bioinformatics, computational biology, genomics, or a related field.

🔬 Technical expertise:

• Proficient in programming languages such as Python for bioinformatics analysis

• Advanced knowledge of bash scripts, version control systems like Git, and experience building bioinformatics pipelines

• Hands-on experience with Nanopore sequencing data analysis and familiarity with associated bioinformatics tools and platforms

👩 🔬 Expertise:

• In-depth understanding of comparative genomics, phylogenetics, and evolutionary biology

• Familiarity with essential biological databases for genomics and metabolic modeling, such as KEGG, MetaCyc, NCBI, UniProt, and BiGG Models

• Experience in assembling, annotating, and assessing the quality of genomic data

🔎 Research skills:

• Strong background in microbial genomics or soil microbiology, with a particular interest in third-generation sequencing technologies

• Ability to independently conduct literature reviews and data mining to support genomics research and pathway analysis.

📊 Analytical skills:

Exceptional analytical and problem-solving abilities, with proven experience in interpreting complex genomic data

🤝 Communication Skills:

• Excellent communication and presentation skills, able to effectively present results to scientific and non-scientific audiences

• Experience in writing scientific papers or reports and contributing to collaborative research projects

• Fluency in English

• Demonstrated ability to work effectively in a dynamic and collaborative environment, preferably in a start-up or research context

1. A screening with our HR manager

2. An interview with our Bioinformatics Manager

3. Last interview with our COO and CEO on values and culture

4. Let's start! 🚀